Document Details

Document Type : Article In Journal 
Document Title :
Effect of Periodontal Disease Severity on Altered Neutrophil Response in Diabetic Patients
Effect of Periodontal Disease Severity on Altered Neutrophil Response in Diabetic Patients
 
Document Language : English 
Abstract : Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to defective secretion or activity of insulin. Periodontitis presents a challenge in the control of DM, due to the infectious burden. Objective: The aim of the present study was to evaluate superoxide production and protein kinase C activity in neutrophils of diabetic patients with periodontal disease. Methods: Fifty diabetics were included and grouped into various degrees of periodontitis severity based on clinical and radiographic evaluation. Forty five healthy volunteers with no signs of periodontitis or diabetes were used as controls. Superoxide production and the localization of protein kinase C (PKC) were compared in resting and FMLP or PMA-stimulated neutrophils. Superoxide production was evaluated by reduction of cytochrome C, while PKC activity was measured by the phosphorylation of histone with radiolabeled ATP. Results: Both resting and FMLP or PMA stimulated neutrophils from diabetic patients with severe periodontitis produced significantly more superoxide than diabetics without periodontitis and diabetics with mild or moderate periodontitis (p 
ISSN : 0 
Journal Name : JDR 
Volume : 1256 
Issue Number : 1 
Publishing Year : 2003 AH
2003 AD 
Article Type : Article 
Added Date : Tuesday, May 20, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ممدوح كريمةKarima, Mamdouh InvestigatorDoctoratemkarimah@kau.edu.sa

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 Effect of Periodontal Disease Severity.pdf pdf 

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