Document Details

Document Type : Article In Journal 
Document Title :
"Calcitonin gene-related peptide-like immunoreactivity in botulinum toxin-paralysed rat muscles"
"Calcitonin gene-related peptide-like immunoreactivity in botulinum toxin-paralysed rat muscles"
 
Document Language : English 
Abstract : Changes in calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) at the motor endplates of botulinum toxin-paralysed rat muscles were investigated using immunohistochemistry. One day following toxin injection, a dramatic increase in CGRP-LI was detected at the motor endplates and within preterminal axons of the soleus and gastrocnemius muscles. The upregulation of CGRP-LI persisted throughout the period during which muscle fibres were paralysed and new neuromuscular junctions were being formed by the growing sprouts. Decline of CGRP-LI at the motor endplates coincided with clinical recovery. Both up- and down-regulation of CGRP-LI took place earlier in the soleus than in the gastrocnemius muscle. Up-regulation of CGRP-LI was also detected in a subpopulation of motor axons in the sciatic nerves and in the spinal motor neurons innervating the paralysed muscles. These results indicate that levels of CGRP are regulated, at least partly, by changes in the target innervation. They also suggest an important role for CGRP in the regenerative processes following muscle paralysis. 
ISSN : 12374706 
Journal Name : Neuromuscular Disorders 
Volume : 4 
Issue Number : 4 
Publishing Year : 1994 AH
1994 AD 
Article Type : Article 
Added Date : Sunday, March 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
شريف حسنHassan, Sherif ResearcherDoctorate 

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