Document Details

Document Type : Article In Journal 
Document Title :
"Superfluous axonal branches following botulinum toxin injection in rat"
"Superfluous axonal branches following botulinum toxin injection in rat"
 
Document Language : English 
Abstract : In order to determine the fate of the superfluous neuromuscular junctions (NMJs) formed during the course of botulinum toxin (BoTx)-induced paralysis, we have quantified the change in the total length of the nerve muscle contact area(s) following BoTx injection into rat calf muscles. The results indicate that: (1) at least some of the superfluous NMJs are eliminated following muscle recovery; (2) synapse elimination is a slow process, as 4 months after recovery it was not yet complete; (3) muscles with different content of type I and II fibers follow a different time course during synapse formation and elimination. We further investigated the possibility that the neural cell adhesion molecule (NCAM) would be the element whose loss from the NMJ might play a role in synapse elimination. Using immunofluorescence and immunoelectron microscopy we show that NCAM is exclusively localized between nerve terminals and Schwann cells and not between nerve terminals and muscle. This localization was maintained throughout paralysis and following recovery, suggesting that NCAM does not play a role in synapse elimination. 
ISSN : 1658-3175 
Journal Name : Journal of Neurology 
Volume : 242 
Issue Number : 2 
Publishing Year : 1995 AH
1995 AD 
Article Type : Article 
Added Date : Sunday, March 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
شريف حسنHassan, Sherif ResearcherDoctorate 

Files

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