Document Details

Document Type : Article In Journal 
Document Title :
“Ciliary neurotrophic factor immunoreactivity in rat intramuscular nerves and neuromuscular junctions”
“Ciliary neurotrophic factor immunoreactivity in rat intramuscular nerves and neuromuscular junctions”
 
Document Language : English 
Abstract : In order to better understand the role played by the ciliary neurotrophic factor (CNTF) during nerve growth, we have investigated the localization of this factor in normal skeletal muscle and neuromuscular junctions of the rat. In addition, we have investigated the changes in CNTF immunoreactivity in botulinum-toxin-paralyzed rat muscle. This animal model was characterized by local muscle inactivity which was accompanied by profuse terminal nerve growth. The results showed that CNTF immunoreactivity in normal rat muscle was localized in Schwann cells surrounding myelinated intramuscular- and preterminal nerve fibres. No staining was seen in Schwann cells overlying the unmyelinated nerve terminals nor within axons or nerve terminals. Secondly, we have demonstrated that CNTF immunoreactivity did not show any changes in botulinum-toxin-paralyzed muscle from the control muscle (neither during terminal nerve growth nor during the formation of new neuromuscular junctions). In view of the present findings, and previous reports, it is suggested that CNTF has no role during growth of nerve fibres, but rather during the process of myelination, or perhaps, thickening and maturation of nerve fibres. 
ISSN : 3185-4152 
Journal Name : Al-Azhar Medical Journal 
Volume : 4 
Issue Number : 32 
Publishing Year : 2003 AH
2003 AD 
Article Type : Article 
Added Date : Sunday, March 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
شريف حسنHassan, Sherif ResearcherDoctorate 

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