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Document Type |
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Article In Journal |
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Document Title |
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EVALUA TION OF THE REGENERATIVE POTENTIAL OF SIMV ASTATIN AROUND IMMEDIATE DENTAL IMPLANTS IN FRESHLY EXTRACTED SOCKETS: AN EXPERIMENTAL STUDY تقييم القدرة التجديدية للسمفاستتين حول الغرسات السنية الفورية في اماكن الخلع : دراسة تجربية |
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Document Language |
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English |
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Abstract |
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Immediate implants are widely used nowadays in an attempt to reduce post-extraction alveolar
bone resorption associated with delayed implantation. Nevertheless, due to discrepancy between the
.transversal diameters.of the socket and of the implant, a gap may generate between the bony walls
of the socket and the neck of the implant. Simvastatin, a cholesterol lowering drug, is used
systemically in treatment of osteoporosis due to its demonstrated bone forming potential. In the
current work, the studied drug was formulated as granules in cellulosic polymeric matrix (Hydroxy
propyl methyl cellulose HPMC) in Faculty of Pharmacy, Alexandria University to be used locally
around immediate implants. Eight dogs in the present study were used to evaluate clinically and
histologically the effect of local application of Simvastatin granules around immediate implants. A
split mouth design was used. In all dogs, under general anesthesia, flaps were reflected and
extraction of left and right mandibular third premolars was surgically and atraumatically performed.
The right side of the mandible was considered as the study group, where acid-etched, sand-blasted,
large grit Microdent implants (3.5 mm in diameter; 10 mm long) were immediately seated around
which Simvastatin granules (2.2mg) were packed; whereas the left side of the mandible constituted
the control group where only implants were placed. Four dogs were sacrificed at 3 weeks, and the
remaining four were euthanized at 3 months. The animals were clinically evaluated the day of
saerifice for gingival color and bleeding. After decalcification, the implants were removed and
specimens were processed and stained with H & E and Gomori's Trichrome stains. Histologic
evaluation was performed for determination of type of healing, and tissue reaction in both groups.
All cases showed uneventful clinical healing without signs of infection, but the study group
manifested better and faster healing as regards the gingival colour and bleeding. Histological
results were favourable in both groups, with better findings in Simvastatin filled defects where bone
regeneration was evident from host bone to implant site ; neo-vascularization and absence of
inflammatory cells were also apparent in this group. It could be concluded that Simvastatin
granules around immediate implants result in osteogenesis filling the space around the implant more
preferablythan control group. Moreover,Simvastatincould be an alternative to guided bone
regeneration. |
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ISSN |
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0 |
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Journal Name |
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Egyptian Dental Journal |
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Volume |
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52 |
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Issue Number |
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3 |
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Publishing Year |
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1426 AH
2006 AD |
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Article Type |
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Article |
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Added Date |
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Monday, October 18, 2010 |
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Researchers
| غادة منصور | Mansour, Ghada | Investigator | Doctorate | |
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