Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Carcinoma of the nasopharynx: The Edmonton experience Carcinoma of the nasopharynx: The Edmonton experience |
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Document Language |
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English |
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Abstract |
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of the nasopharynx is a rare neoplasm in the United States and Western Europe. It is more common in southern Chinese, Southeast Asian, northern African and Eskimo populauons '-'. In southern China, the annual in .idencc of carcinoma of the nasopharynx is 15-50 per 100 0003 The median age at which the tumour is diag¬nosed in southern China is between 40 and 50 years and is more common in men. The majority (95%) of the tumours are of an undifferentiated type (World Health Organiza¬tion), They are not associated with cigarette smoking or alcohol, and less than 5% of these cases are squamous cell carcinoma (Grade If
The likely aetiological factors incIude genetic suscep¬tibility, consumption of food with high salt content, and Epstein-Barr virus5-7, In "nonendemic" countries, there is a lack of association with Epstein-Barr virus and poorer survival after external beam radiation therapy8.9.
Carcinoma of the nasopharynx is a radiosensitive tumour and radical external beam radiotherapy is the standard therapylO-J2. Local relapse represents the major problem and is the most common cause of failure, The incidence of local relapse is 30-60%'O,12,lJ and the most important prognostic factor in local failure is the extent of primary disease at the time of presentationIO.J3-15.
Carcinoma of the nasopharynx is also chemosensi¬tive, especially to platinum-based combinations I 6--1 9, Com¬bined radiotherapy and chemotherapy regimens aloe frequently used in the management of advanced carcino¬mas and the response rates have generally been higher than that of other head and neck cancers. Although the overall survival has not been significantly improved, large randomised trials of adjuvant chemotherapy have demon¬strated a reduction in the rate of development of distant mctastases-P?'.
The survival rate for early stage disease is good; however, many patients present with advanced stages of the disease. The average 5-year survival rate reported for patients with stage III disease after radiotherapy is 46% (54% in the present series) and for stage IV disease approxi¬mately 30% (33%). The presence of bulky cervical lymph
node metastases or supraclavicular lymph node metas¬tases has been shown to be associated with an increased incidence of distant metastases, local failure after radio¬therapy, and a 5-year survival rate of only 10--40%22-25. We report here a retrospective analysis of 172 patients with squamous cell carcinoma of the nasopharynx treated at the Cross Cancer Institute, in northern Alberta between 1975 and 1 ~96, Candidate prognostic factors are reviewed and their impact on overall survival and disease-free survival are presented. |
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ISSN |
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1110-5607 |
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Journal Name |
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CURRENT ONCOLOGY |
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Volume |
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7 |
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Issue Number |
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2 |
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Publishing Year |
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1416 AH
1996 AD |
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Article Type |
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Article |
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Added Date |
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Friday, January 14, 2011 |
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Researchers
| محمود الاحول | AI-Ahwal, Mahmoud | Researcher | Doctorate | |
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