Document Details

Document Type : Article In Journal 
Document Title :
Evaluation of the fluorescence polarization immunoassay for quantitation of digoxin in serum
Evaluation of the fluorescence polarization immunoassay for quantitation of digoxin in serum
 
Subject : Internal Medicine 
Document Language : English 
Abstract : Digoxin in serum was measured by fluorescence polarization immunoassay (FPIA) and by radioimmunoassay (RIA). Intraday precision of the FPIA method determined by replicate analysis of three controls (low, medium, and high) gave coefficients of variation of 5.41, 2.67, and 2.37%, respectively. The interday coefficients of variation were 5.71, 4.55, and 1.93% for the low, medium, and high controls, respectively. The mean recovery for three spiked controls was 98%. Quantitative results obtained by FPIA on serum samples from patients receiving digoxin were compared with the results obtained by RIA. The correlation coefficient was 0.989. The stability of the standard curve in FPIA was evaluated by recalibrating the instrument at two intervals, 21 days apart, and superimposing the standard curve. No significant changes were found in polarization values 
ISSN : 1536-3694 
Journal Name : Therapeutic Drug Monitoring 
Volume : 6 
Issue Number : 4 
Publishing Year : 1404 AH
1984 AD 
Article Type : Article 
Added Date : Monday, November 28, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالله الفارسAl-Fares, Abdullah InvestigatorDoctorate 
سراج ميرهMira, Siraj ResearcherDoctorate 

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