|
Document Type |
: |
Article In Journal |
|
Document Title |
: |
Comparative Immunogenicity of Two Recombin~nt lJepatitis B Vaccines Given to Infants Comparative Immunogenicity of Two Recombin~nt lJepatitis B Vaccines Given to Infants |
|
Document Language |
: |
English |
|
Abstract |
: |
Thrcc hundrcd hc~lthy infants vaccinated with lO~g dose of recombinant hepatitis B Smith
Klinc vaccinc at 2, 4& 6 months of agc were randomly enrolled in the study. Blood samples were
takcn at 9 and 18 months of age, sera were tested for HBs Ag, antibody to hepatitis B core antigen
and quantitatively for antibody to hepatitis B surface antigen (anti-lIBs) using commercial enzyme
immunoassay kits. The results were compared with that of our previous studies using a'2.5 ~g dose
of recombinant hepatitis B Merck Sharp vaccine using three different dosing schedules (2, 4, 6 M,
0, 2, 6 M and 2.4, 9 M) Smith Kline vaccine gave 98.3% seroprotection rate, 95.2% of infants had
good 01' excdlent response with geomeh'ic mean anti 118s titers equal to 352.4 mlU/ml. At 18
months, the scroprotection dl'OIJIJedto 96'Yogood or excellent response was found in 78% and the
geometric mean anti B8s titers was 98.2 mlU/ml. The seroprotection rate and the anti BBs
geometric mean titers in infants vaccinated with the Smith Kline vaccine were significantly higher
than those vaccinated with the MerckSharp vaccine in two schedules (2, 4, 6 and 0, 2, 6 M) and they
were similar for schedule 2, 4, 9 M at 9 months, at 18 months, the drop in the anti HBS titers was
significantly greater with all Merck Sharp vaccine schedules. |
|
ISSN |
: |
1110-2179 |
|
Journal Name |
: |
EGYPTIAN JOURNAL OF MEDICAL MICROBIOLO |
|
Volume |
: |
8 |
|
Issue Number |
: |
3 |
|
Publishing Year |
: |
1420 AH
1999 AD |
|
Article Type |
: |
Article |
|
Added Date |
: |
Sunday, April 22, 2012 |
|
Researchers
| منى حسن | hassan, mona | Researcher | Doctorate | |
|