Document Details

Document Type : Article In Journal 
Document Title :
COMPARATIVE IMMUNOHISTOCHEMICAL STUDY ON OSTEOCALCIN EXPRESSION IN FIBROUS DYSPLASIA AND OSSIFYING FIBROMA
COMPARATIVE IMMUNOHISTOCHEMICAL STUDY ON OSTEOCALCIN EXPRESSION IN FIBROUS DYSPLASIA AND OSSIFYING FIBROMA
 
Document Language : English 
Abstract : Objective: Fibrous dysplasia (FD) and ossifying fibroma (OF) show similar histological and radiological features, making distinction between them a diagnostic dilemma requiring clarification. Study Design: Forty (20 FD, 20 OF) paraffin-embedded specimens were immunohistochemically stained using the primary antibody Osteocalcin (OC). The immunostained area fraction was evaluated in the bone trabeculae alone and in both the bone trabeculae and the connective tissue stroma together. Results: All cases of FD and OF demonstrated OC immunostaining in both the bone trabeculae and the stromal cells. In FD, osteocalcin was more expressed in stromal cells, while in OF, immunoreactivity was more marked in bone trabeculae. The area fraction expressing OC in both the bone tarbeculae and fibrous stroma was significantly higher in FD than OF (p= 0.025). Conclusion: The stromal spindle-shaped cells in FD are of the osteoblastic lineage. Osteocalcin expression can be a significant support in differential diagnosis of FD and OF. 
ISSN : 1359-8546 
Journal Name : INTERNATiONAL JOURNAL of ACADEMIC RESEARCH 
Volume : 5 
Issue Number : 1 
Publishing Year : 1434 AH
2013 AD 
Article Type : Article 
Added Date : Monday, December 10, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عواطف دازارDzar, Awatef ResearcherDoctorate 

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