تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
The Diagnostic Value of Immunohistochemistry in the Diagnosis of Primary and Secondary Hepatic Carcinomas
The Diagnostic Value of Immunohistochemistry in the Diagnosis of Primary and Secondary Hepatic Carcinomas
 
الموضوع : علم الأمراض 
لغة الوثيقة : الانجليزية 
المستخلص : Metastatic adenocarcinoma to the liver from an unidentified primary tumor site is a common diagnostic problem. The present study included 41 cases of histologically diagnosed liver biopsies including hepatocellular carcinoma, cholangiocarcinoma and metastatic carcinoma in the liver. All cases were stained immunohistochemically with Cytokeratin 18, 7, and 20, Carbohydrate Antigen 19-9 and Alpha-fetoprotein to evaluate their usefulness in differentiating these tumor entities. Cytokeratin 18 was positive in 87.5% of hepatocellular carcinoma; all cases of cholangiocarcinoma, and metastatic carcinoma. Cytokeratin 7+ve/Cytokeratin 20-ve pattern was identified in 12.5% of hepatocellular carcinoma, 100% of cholangiocarcinoma, one metastatic pancreatic carcinoma, and all metastatic gastric carcinomas (100%). On the other hand, Cytokeratin 7-ve/Cytokeratin 20+ve were identified in colorectal carcinoma metastatic to the liver. CA19-9 showed positive immunoreactivity in all studied cases. AFP positive immunostaining was identified in 43.7% of hepatocellular carcinoma while it was negative in all other tumors. It was concluded that Cytokeratin 18 was of no benefit in the differential diagnosis of primary hepatic carcinoma and metastatic cases from any site. Cytokeratin 7 and CA19-9 positive staining can exclude a diagnosis of hepatocellular carcinoma, but cannot discriminate between metastatic carcinoma (from stomach, pancreaticobiliary origin) and cholangiocarcinoma. The Cytokeratin 20+/Cytokeratin 7–ve phenotype indicates metastatic intestinal adenocarcinoma, most often from the colon or rectum 
ردمد : 1319-1004 
اسم الدورية : مجلة العلوم الطبية 
المجلد : 16 
العدد : 4 
سنة النشر : 1430 هـ
2009 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Wednesday, October 5, 2011 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
علي صوانSawan, Ali باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 30979.pdf pdf 

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